This latest Blog posting, as the title may suggest, contains some, hopefully, useful tools and resources that are available to the synthetic chemist over the internet. By that I don't mean Linkedin, FB or any other website you may care to browse during your coffee break (I don't want to know...) but useful tools such as common nmr chemical shifts of solvents, boiling point calculators and the like, the sort of thing we used to look up in text books (remember those?) the longer term aim of this will be to get a collection of useful links on our web site to provide a "one stop" resource for useful "stuff."
If anyone would like to suggest links to include, please email me.
Anyway, before we get to that, a few news items and chemistry highlights that I've stumbled across in the last couple of months since my last blog.
Conformetrix, who use their novel NMR based technique to determine extremely accurate 3D structures to help develop proprietary drugs against therapeutically important targets, recently announced their first collaborative agreement with AstraZeneca, more on this story can be found here. Good news and smiles all round as one of my ex colleagues is working there (Conformetrix, not AZ obviously) and he was probably looking more like Ricky Gervais than ever on receipt of the news!!
Some other ex colleagues have started up Reach Separations, based at BioCity in Nottingham, they specialise in a range of separation services using both HPLC and SFC, with a wealth of experience in analytical and preparative chromatography both chiral and achiral, worth giving them a shout if you've got a chromatography need, good luck guys!!
Some chemistry now, nice bit of flow chem from Kupracz et al who've developed the first telescoped protocol for preparing vinyl azides from the corresponding alkenes in flow. They've employed two functionalized polymers serving as packed-bed materials inside the reactor, then gone on to show that the copper-catalyzed vinyl triazole formation from these vinyl azides in the presence of alkynes is possible using elemental copper as an inductively heatable material avoiding the use of iodine azide, which is a good thing!
The guys have out it all on video so you can get a better feel for the kit used to carry out the chemistry, nice panaoramic shot of the Uni too.....
Further flow highlights come from our friends at Cambridge Uni and Microsaic, who've just published some work on using MS monitoring in flow, analytics in continuous processing will be something of a growth area in the next few years I think, particularly if people can "close the loop" (pun fully intended) and generate the next experiment based on analytical data.
Useful conversion of thiols into sulphonyl chlorides from Hojat Veisi of Payame Noor University using NCS, nice, mild way of generating these useful intermediates.
OK, now onto the resources bit, I've put together a few links to some web resources for Chemists, as i said in the intro, I would like to grow this into a feature on the Asynt web site so any additional links you think would be useful to others, please share.
I think that's about it for this issue, happy surfing!